Community Research and Development Information Service - CORDIS

Periodic Report Summary 1 - MEMOTUMCELLMACH (Metallodrugs to Modulate Tumour Cell Machinery)

The general aim of this proposal is to create pH-responsive metalloorganic molecular switches capable of freeing a coordination position upon a pH drop, that is, capable of activation towards biomolecule interaction within cells in a pH-dependent manner. To this end, two systems have been developed, a ruthenium arene and an organoiridium switch.
The ruthenium project has pioneered the establishment of the switchable system. In a general structure [Ru(eta6,kappa1-arene,N)(L^L’)]Cl2 (where L^L’ is a chelating ligand), changes in the different ligands around the metal have led to an understanding of which electronic and steric features of the different building blocks can help tailor the pH of activation. Most importantly, our design allows for deactivation upon drop in the proton concentration (increase in the pH). The dynamics of the switch have been carefully studied and have allowed us to conclude that the rates at which both processes (activation and deactivation) occur are also pH dependent. The iridium and osmium project, still in its infancy, are greatly benefiting from the findings laid out by the studies of the ruthenium system.
The grant is greatly contributing to the consolidation of the fellow (Dr Pizarro) and her group at the host institution, and to the establishment of new national and international collaborations.

Reported by

FUNDACION IMDEA NANOCIENCIA
Spain

Subjects

Life Sciences
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