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Engineering protein O-glycosylation for the production of receptor blockers

Production methods for mucin type receptor blockers, namely O-glycosylated peptides, have been developed. In vivo and in vitro synthesis of selectin blockers are considered. In vivo synthesis by installation of new glycosylation pathways in CHO-cells and in vitro synthesis of O-glycans using glycosyltransferases produced at an industrial scale in CHO-cells, combined with recycling pathways for sugar nucleotide substrates have been studied.

Reported by

Kernforschungsanlage Jülich GmbH
5170 Jülich