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ERC

MEM-STRUCT-AFM Report Summary

Project ID: 310080
Funded under: FP7-IDEAS-ERC
Country: France

Final Report Summary - MEM-STRUCT-AFM (The Structure and Assembly of Membrane Proteins in Native Membranes studied by AFM)

High-Speed Atomic Force Microscopy: The dawn of dynamic structural biochemistry:
The advent of high-speed atomic force microscopy (HS-AFM1) has opened a novel research field for the dynamic analysis of single bio-molecules: Molecular motor dynamics2,3 membrane protein diffusion4,assembly5 and conformational changes6 could be directly visualized. Further developments for buffer exchange7 and temperature control8 during HS-AFM operation provide breakthroughs towards the performance of dynamic structural biochemistry using HS-AFM.
1) Ando et al, Chem Rev 2014, 114(6):3120-88
2) Kodera et al, Nature 2010, 468(7320):72-6
3) Uchihashi et al, Science 2011, 333(6043):755-8
4) Casuso et al, Nat Nanotechnol 2012, 7(8):525-9
5) Chiaruttini et al, Cell 2015, 163(4):866-79.
6) Ruan et al, PNAS 2017, doi: 10.1073/pnas.1616413114
7) Miyagi et al, Nat Nanotechnol 2016, 11(9):783-90
8) Takahashi et al, Small 2016, 12(44):6106-6113

Reported by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
France
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