Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Inert oxygen-carrying perfluorocarbons as body fluid replacements

New biocompatible and haemocompatible perfluorocarbon emulsions are being developed to be used in in vivo and in vitro medical work. Several novel formulations of perfluorocarbon-based emulsions for use as respiratory gas-carrying fluids were developed and evaluated in relevant biological systems, including specially-developed in vitro bioassays. Some of the new emulsions incorporated novel and highly-purified fluoro-surfactants and newly-synthesised fluorinated stabilizers which significantly improved emulsion stability and increased storage time. The emulsions were steam sterilizable and storable at room temperature for over 1 year. In vivo gross toxicity assessments of selected emulsions at clinically-relevant doses showed satisfactory results. Some emulsions were assessed as perfusates of isolated vertebrate organs, where ex-vitro vital functions were markedly improved. Some of the novel fluoro-surfactants inhibited human platelet aggregation in vitro in a dose-dependent manner, suggesting novel and clinically-important potential applications as anti-thrombotic agents. Applications for this technology include: temporary blood replacement fluids in transfusion medicine; organ perfusion, preservation and protection solutions; extracorporeal pump-priming fluids; respiratory gas-carrying cell culture media supplements; anti-thrombotic and anti-haemostatic drugs.

Reported by

Université de Nice
Parc Valrose
06108 Nice
France
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