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Development of highly selective and robust MIPs for clenbuterol and ß-lactam antibiotics and their application to food analysis

Highly selective and robust MIPs have been developed for ß-lactam antibiotics and clenbuterol. The results of the study indicate that MIPs can be used to prepare both selective and general recognition matrices for either individual analytes (e.g. penicillin) or groups of compounds (e.g. the ß-lactam antibiotic group). The MIPs developed have shown very good reproducibility and stability. Practical protocols for the use of the MIPs as solid phase selective absorbents for the analysis of food samples have been developed and briefly evaluated. Specific MIP-based separation of clenbuterol from meat and kidney, and of a ß-lactam antibiotic (oxacillin) from milk, has been shown. Independent evaluation of the clenbuterol MIPs by the European MICA Network Group also demonstrated good reproducible performance.

Reported by

LEATHERHEAD FOOD RESEARCH ASSOCIATION
RANDALLS ROAD
KT22 7RY LEATHERHEAD
United Kingdom
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Subjects

Biotechnology - Food
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