Community Research and Development Information Service - CORDIS



Project ID: QLK3-CT-1999-00413
Funded under: FP5-LIFE QUALITY
Country: United Kingdom

Improved secretion

Gram-positive bacteria of the species Bacillus are well known for the high levels of secretion of several of their homologous proteins. Attempts to secrete heterologous proteins at high levels have, however, often met with little success. An important result from this project was that mutations in the dlt operon, responsible for the alanylation of cell wall teichoic acids, resulted in a significant increase in the production of a number of secretory proteins, including Bacillus amylases, and the protective antigen (PA) of Bacillus anthracis. This finding holds promise for the improved secretion of other (heterologous) proteins. The results have been published in the international scientific literature and a patent was filed.

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Colin HARWOOD, (Head of Molecular Microbiology Group)
Tel.: +44-1912-227708
Fax: +44-1912-227736
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