Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

Characterisation of adult and pediatric T cell responses to the gluten and gluten like epitopes in wheat, barley, rye and oats

Intestinal T cell responses in number of children and adults to T cell epitopes in wheat gluten, and gluten like epitopes in wheat, barley, rye and oats have been examined. The results demonstrate that there are T cell responses to a number of epitopes both in children and adults, but also that there exists a hierarchy with respect to how frequently the epitopes are recognised.

Almost all patients have intestinal T cells reactive to some T cell epitopes of alpha-gliadin in wheat whereas responses to most other epitopes are more variable. Although there exist some peptides that are recognised in their native sequence, most epitopes are only or better recognising when certain glutamine residues have been converted to glutamate (i.e. deamidation).

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