Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

FP5

NEUROSTEROIDS & AGEI Informe resumido

Project ID: QLK6-CT-2000-00179
Financiado con arreglo a: FP5-LIFE QUALITY
País: United Kingdom

Tonic neurosteroid tone

A novel concept, which has emerged, is the existence of a tonic neurosteroid tone within brain regions such as hippocampus, which is critically involved in cognitive processes. Thus, interactions of endogenous 3a, 5a-tetrahydroprogesterone with GABAA receptors was promoted by application of two types of inhibitors:
- Of the SULT1A1, a sulfotransferase which converts biologically active 3a, 5a-tetrahydroprogesterone to its biologically inactive sulfated form ;

- Of the 3a-HSOR, an enzyme involved in the synthesis and degradation of 3a, 5a-tetrahydroprogesterone.

Application of these inhibitors indeed resulted in prolonged miniature inhibitory postsynaptic currents (mIPSCs) recorded from hippocampal neurons. By contrast, these inhibitors did not directly interact with the GABAA receptors.

Reported by

University of Dundee
Ninewells Hospital and Medical School
DD1 9SY Dundee
United Kingdom
See on map
Síganos en: RSS Facebook Twitter YouTube Gestionado por la Oficina de Publicaciones de la UE Arriba