Community Research and Development Information Service - CORDIS

Method for phylogeny based identification of diagnostic DNA sequence motifs

The result is a method for identification of diagnostic sequence motifs from a matrix of related DNA sequences.

It builds on a four step approach: sequence alignments, character based phylogenetic analysis, mapping of features of particular interest and relevance (host specificity, toxin profiles, geographical origin, pathogenicity), and finally tracing the diagnostic sequence motifs from the phylogenetic tree(s).

The method can be used to develop reliable diagnostic assays for practically any group of biological organisms, provided sufficient DNA sequence data is available. Mining, exploring and exploiting the present large sequence databases, is a logical step in the post genomic area. The approach is described and exemplified in scientific papers to be published in inter nation peer-review journals.

The method has no direct commercial use potential but may be used as a tool for development of methods that can be commercialised.

More information on the DETOX-FUNGI project can be found at: http://detox.ba.cnr.it.

Related information

Reported by

National Veterinary Institute
ULLEVAALSVEIEN 68
0106 OSLO
Norway
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