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DETOX-FUNGI Informe resumido

Project ID: QLK1-CT-1999-01380
Financiado con arreglo a: FP5-LIFE QUALITY
País: Norway

Method for phylogeny based identification of diagnostic DNA sequence motifs

The result is a method for identification of diagnostic sequence motifs from a matrix of related DNA sequences.

It builds on a four step approach: sequence alignments, character based phylogenetic analysis, mapping of features of particular interest and relevance (host specificity, toxin profiles, geographical origin, pathogenicity), and finally tracing the diagnostic sequence motifs from the phylogenetic tree(s).

The method can be used to develop reliable diagnostic assays for practically any group of biological organisms, provided sufficient DNA sequence data is available. Mining, exploring and exploiting the present large sequence databases, is a logical step in the post genomic area. The approach is described and exemplified in scientific papers to be published in inter nation peer-review journals.

The method has no direct commercial use potential but may be used as a tool for development of methods that can be commercialised.

More information on the DETOX-FUNGI project can be found at:

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National Veterinary Institute
0106 OSLO
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