Community Research and Development Information Service - CORDIS


PROBE Report Summary

Project ID: Q5RS-2000-31457
Funded under: FP5-LIFE QUALITY
Country: United Kingdom

Identification of virulence mechanisms of pathogens of larval turbot and use of this knowledge in selection of probiotic bacteria

Vibrio splendidus was identified as the cause of major mortalities in larval turbot rearing and in studies to identify the mechanism by which this occurs we have identified the gene for a cytotoxin closely related to an established toxin involved in enteric infections in humans. For the toxin we identified, inactivation of this gene renders the organism harmless to turbot larvae yet the bacteria still colonise the larval intestinal tract in high numbers.

Expression of the toxin gene is subject to control by a regulatory gene related to a well-established group of virulence gene regulators but of a structure previously unknown. This knowledge allows a more rational selection of probiotic organisms to prevent intestinal tract infections.


Harry BIRKBECK, (Head of Unit)
Tel.: +44-141-330-5843
Fax: +44-141-330-4600
Record Number: 36111 / Last updated on: 2005-04-12
Information source: e-TIP
Collaboration sought: Further research or development support, Information exchange/Training
Stage of development: Scientific and/or technical knowledge (basic research)
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