Community Research and Development Information Service - CORDIS


AGEING MUSCLE Report Summary

Project ID: QLK6-CT-1999-02034
Funded under: FP5-LIFE QUALITY
Country: Slovenia

Frequency of myonuclei in young and old human muscles

The data on the frequency of myonuclei obtained in young and old human muscles can serve as a standard when comparing the distribution and frequency of myonuclei in pathological, disused or differently trained muscles. Absolute numbers of myonuclei within unit tissue volumes are important references for in vitro studies:

- Number of muscle nuclei per mm fibre length: 99.88 ± 5.97 in the young, 123.83 ± 14.38 in the old muscle (non significant difference);

- Number of myonuclei in 1cm3 of human vastus lateralis muscles:2.73 ± 0.13 (SEM) x 107 in the young, 3.00 ± 0.11 (SEM) x 107(non significant difference);

- Nuclear domains: 37.96 ± 2.56 mm3x 103 in the young, 35.54 ± 2.01 mm3x 103 in the old muscle.

These results might also be interesting for comparison among different species.


Ida ERZEN, (Scientific Councillor)
Tel.: +386-1-5437312
Fax: +386-1-5437301
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