Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

FP5

AGEING MUSCLE Résumé de rapport

Project ID: QLK6-CT-1999-02034
Financé au titre de: FP5-LIFE QUALITY
Pays: Sweden

Identification and quantification of human satellite cells during ageing

Different staining techniques for identification of satellite cells in human muscles have been evaluated. Several methods give an estimation of frequency of satellite cells however no golden standard has been established, as different markers for satellite cells do not give the same numbers.

This suggests that either there are different populations of satellite cells or they show different degrees of activation. One efficient staining method using antibodies against N-CAM to visualize satellite cells has been used to quantify the number of satellite cells in persons at different ages, from newborns, children aged 2-7 years, young adults and aged persons (over 70 years). In children the number of satellite cells are 2,5-3 folds higher than in young adults that in turn are 2-3 folds higher than in aged people.

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Lars-Eric THORNELL, (Full Professor)
Tél.: +46-90-7865142
Fax: +46-90-7865480
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