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Project ID: IST-2001-33141
Finanziato nell'ambito di: FP5-IST
Paese: Ireland

Development of a medical device suitable for effective electroporation of intraluminal tissue and optimisation of electroporation parameters associated with its use

The Cork Cancer Research Centre has invented (jointly with the NMRC and Gaeltec) a device "EndoVac", suitable for electroporation of intraluminal tissue and designed for simple integration onto a endoscope/laproscope head. The device consists of a hollow chamber within which a pair of parallel planar macroeletrodes are contained. These electrodes can effectively electroporate several cm cubed of tissue with one pulse from the connected cythorlab unit. Potentially the silicon needle electrodes produced by the NMRC may expand the application of the device towards transdermal delivery of genes and drugs. Research carried out at the CCRC initially identified parallel planar electrodes as optimum for effective electroporation, and extensive work was carried out on the reduction to practice of the unit. The electroporation parameters were examined using a flow cytometry unit to examine molecular cell entry (altered pulse frequency, number, voltage and length) and also genetic based reporter genes (luciferase) identified the optimum pulse types both in-vitro and in-vivo. The market for this unit includes both the cancer therapeutics area but the application can also be expanded to include the treatment of diseased organs accessible endoscopically. Once all IPR issues have been resolved an extensive dissemination of the information gained will be carried out via peer reviewed journals and through presentations both in the EU and the USA.

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