Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Impact of prion replication on anti-oxidant defence

In collaboration with Partner 4 we could demonstrate in a previous work that infected cells present a higher susceptibility to oxidative stress (Milhavet et al). In addition as reported in paragraph 1.2, we demonstrated that metal ion metabolism in perturbed in prion infected cells. This may represent the linked between prion infection and anti-oxydant defence.

Ref:
Rachidi W, Vilette D. Guiraud P., Arlotto M, Riondel J, Laude H, Lehmann S & Favier A (2003) Over expression of prion protein increases cellular copper binding and antioxidant enzyme activities but not copper transport J. Biol. Chem. 278:9064-9072.

Senator A., Rachidi W., Lehmann S., Favier A. & Benboubetra M. (2004) Prion protein protects against DNA damage induced by Paraquat in cultured cells. Free Radical Biology & Medicine. 37, 1224-30.

Reported by

CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE, UPR 1142
141, rue de la Cardonille
34396 Montpellier
France
See on map
Śledź nas na: RSS Facebook Twitter YouTube Zarządzany przez Urząd Publikacji UE W górę