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Effect of oxidative stress on PrP conversion

The effect of oxidative stress on prion infected cells resulted in a higher cell death than in control cell line (Milhavet et al.). Therefore it was difficult to observe significant modification in PrP conversion. When these cells are stressed with metal ions such as Copper, we however observed a decrease in PrP conversion. However, it is not possible to know if this effect relates to the stress induced by Copper or to the impact of the metal ion on the biology and the conformation of the prion protein.

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CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE, UPR 1142
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