Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

FP5

PRP AND NEURODEGENER Résumé de rapport

Project ID: QLG3-CT-2001-02353
Financé au titre de: FP5-LIFE QUALITY
Pays: France

Effect of oxidative stress on PrP conversion

The effect of oxidative stress on prion infected cells resulted in a higher cell death than in control cell line (Milhavet et al.). Therefore it was difficult to observe significant modification in PrP conversion. When these cells are stressed with metal ions such as Copper, we however observed a decrease in PrP conversion. However, it is not possible to know if this effect relates to the stress induced by Copper or to the impact of the metal ion on the biology and the conformation of the prion protein.

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Sylvain LEHMANN, (Head of Group)
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