Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

Apoptotic pathways involved in TSEs 2

With Partner 5 we used a new experimental model where recombinant prion protein was substrate-coated to test its effect on neuronal survival primary culture from early postnatal mouse brain. It was thus shown that PrP could significantly protect cells from apoptosis through a pathway involving PI3 kinase as well as ERK. This pathway might be important in TSEs.

Ref:
Chen S., Mangé A, Dong L, Lehmann S. & Schachner M. (2003) Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival. Mol Cell Neurosci. 2003 2:227-33.

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