Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Apoptotic pathways involved in TSEs 3

We indirectly investigated apoptotic pathways involved in TSE by looking at the role of PrP in neuronal survival (Chen et al. 2003). Notably, in the absence of the cellular prion protein (PrPC), the disease-associated isoform, PrPSc, appears not to be intrinsically neurotoxic, indicating that PrPC itself participates directly in the prion neurodegenerative cascade (Bradner et al., 1996). Neuronal death is a prominent pathological hallmark of prion diseases that can be explained by the loss of PrPC control of neuronal survival. This interpretation is also supported by evidences arising from the work of Solforosi et al., 2004.

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