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Structure of oxygenases involved in cephalosporin biosynthesis

The work has resulted in crystal structures for the enzyme (deacetoxycephalosporin-C synthase ) that converts penicillins into the commercially and medicinally important cephalosporin antibiotics. The structures reveal the unusual way in which the enzyme binds its penicillin substrate and show how the active site of the enzyme can be modified to accept other penicillins, specifically those with hydrophobic side chains. The modified forms of deacetoxycephalosporin-C synthase can be used to develop more efficient routes to the cephalosporin antibiotics

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University of Oxford Chemistry Research Laboratory
12 Mansfield Road
OX1 3TA Oxford
United Kingdom
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