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Enzymes in clavam biosynthesis

The work has resulted in the identification of enzymes that catalyse the formation of the beta-lactam ring in the biosynthesis of important antibiotics including the carbapenems and the ß-lactamase inhibitor clavulanic acid. These enzymes, or modified forms thereof, may be useful in the production of medicinally useful beta-lactam antibiotics.

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University of Oxford Chemistry Research Laboratory
12 Mansfield Road
OX1 3TA Oxford
United Kingdom
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