Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

FP5

ACE Streszczenie raportu

Project ID: EVK1-CT-2001-00100
Źródło dofinansowania: FP5-EESD
Kraj: United Kingdom

Concordances between estrogenic mixture effects in sub-cellular, cell-based and fish assays

Concordance between assays was analysed for single substances, as well as for mixture prediction. For single substance concordance, broadly speaking, in vivo responses are predicted by in vitro assays, for the five chemicals E2, EE2, BPA, OP and NP. Where anomalies were encountered, they were either not significant in a regulatory context (e.g. small fluctuations of relative potencies of xenoestrogens between assays), or were predictable (e.g. the reduced potency of E2 in vivo).

The analyses of mixture effects in the suite of assays employed in ACE demonstrated the capacity for estrogenic chemicals to act together in an additive manner both in vivo and in vitro, according to the principles of CA. This corroborates the working hypothesis of ACE, which states that additive effects are mirrored at increasing levels of biological complexity.

Evidence that estrogenic chemicals behave according to the principles of CA at different levels of biological complexity demonstrates the value of utilising in vitro approaches when trying to establish combination effects of mixtures of estrogenic chemicals. There is considerable potential for extrapolation of this in vitro data to assess whether there may be a risk of significant effects in vivo. This may help to avoid some of the costly and time-consuming whole animal studies used in risk assessment procedures.

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THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON
29-39 Brunswick Square
WC1N 1AX LONDON
United Kingdom
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