Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS


MIVASE Berichtzusammenfassung

Project ID: QLG1-CT-2000-01801
Gefördert unter: FP5-LIFE QUALITY
Land: United Kingdom

Cell biological work has revealed the location and processing of the complex and indicated that one of the isoforms of part of the intramembrane proton channel is probably involved in direction

Subunit a3 the largest of the integral membrane proteins which make up the enzyme complex is responsible for targeting the entire complex to the plasma membrane of osteoclasts and tumour cells. This makes the complex available to agents at the outside surface of the cells. This will facilitate the development of strategies for targetting and inhibiting the enzyme and so compromising cell function.


John FINDLAY, (Head of Research Group)
Tel.: +44-113-33433140
Fax: +44-113-3433167
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