Community Research and Development Information Service - CORDIS

Validation of a Tetracycline conditional expression retroviral vector expressing efficiently and safely a therapeutic gene in glioblastoma in murine models

A tetracycline conditional expression retroviral vector, which has been validated in vitro, is currently being validated for its efficient and safe transduction of a therapeutic gene in models of murine and rat glioblastoma. The vector system is being tested for appropriate propagation and transgene expression within the tumour as well as for any detectable dissemination outside of the tumour. It is also being tested for its therapeutic efficacy, alone or in combination with retroviral vectors transducing other genes of interest.

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UNiversite Pierre et Marie Curie - UMR7087
83 boulevard de l'Hopital
75013 paris
France
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