Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Screening and recruitment procedure of late-middle aged and older subjects

The objective of this study was to report the rational, design, recruitment, baseline characteristics and preliminary overview of volunteers in the ZENITH study. A multi-centre prospective intervention study employing a randomised double-blind design was performed in Clermont-Ferrand, Theix (France), Coleraine (Northern Ireland), Grenoble (France) and Rome (Italy). Healthy men and women middle-aged (55-70 years) and older volunteers (70-87 years) participated in this study. At baseline (prior to Zn supplementation), all volunteers underwent a full clinical examination, anthropometric measurements, health and lifestyle questionnaire, Mini Mental State Examination, Geriatric Depression Scale, biochemistry profile.

In total 842 volunteers (378 men and 464 women) were invited to take part in the study. 49% of these volunteers were excluded on the basis of inclusion/exclusion criteria. 433 participants were admitted to the Zn supplementation for six months. During this period about 10% of volunteers dropped out from the study. A total of 387 subjects (197 males and 190 females) successfully completed the supplementation phase of the ZENITH study.

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