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Long-term moderate zinc supplementation increases exchangeable zinc pool masses in late middle-aged men

Zinc (Zn) supplementation may be beneficial for health. Assessing the exchangeable Zn pools may be a useful approach for evaluating Zn status. We undertook this study to evaluate the long-term supplementation effects of two moderate doses of Zn on the mass of the exchangeable Zn pools. Design: three groups of healthy late middle-aged male subjects (n = 16/group) participated in a stable isotope Zn kinetic study following 6 months of daily supplementation with placebo (0mg) or 15mg or 30mg of supplemental Zn.

At the end of the supplementation period, each subject received an intravenous injection of 1mg of 70Zn, and the plasma Zn disappearance curve was monitored for the next 10d. Two approaches have been applied to determine the characteristics of exchangeable Zn pools: 1) formal tri-compartmental modelling, and 2) a simplified determination of the total mass of the rapidly exchangeable Zn pool (EZP).

The exchangeable Zn pool masses for the three considered pools were as follows: 2.15, 12.7 and 100.5mg Zn. Rapidly exchangeable Zn pool mass was 143mg Zn. Zn supplementation significantly increased exchangeable Zn pool masses regardless of the approach employed to determine these pools. In addition, these data confirmed that Zn exchangeable pool masses correlate positively with total Zn intake and negatively with subject age, but do not correlate with plasma Zn. Our data demonstrated that a long-term supplementation with two moderate doses of Zn is efficient to increase exchangeable Zn pool masses in late middle-aged subjects.

Reported by

Equipe Endocrinologie Mitochondriale et Nutrition UMR 866 Différenciation Cellulaire et Croissance
Centre de Recherche de Montpellier 2
34 060 Montpellier Cedex 1 Place Pierre Viala
France