Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

FP5

RECOMBINANT BCG Streszczenie raportu

Project ID: ICA4-CT-2000-30032
Źródło dofinansowania: FP5-INCO 2
Kraj: United Kingdom

generation of leuD KO rBCG strains

I recombinant BCG strain was generated, rBCG-leuD, in which the leuD gene was deleted. The strain was therefore an auxotroph for the amino acid leucine. This allowed the use of plasmid vectors that provide the leuD gene in trans that complement the leuD mutation. This complementation allows the stable expression of foreign genes in BCG in the absence of antibiotic resistance markers.

Kontakt

Johnjoe MCFADDEN, (Professor of Molecular Genetics)
Tel.: +44-1483686494
Faks: +44-1483300374
Adres e-mail
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