Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

FP5

RECOMBINANT BCG Sintesi della relazione

Project ID: ICA4-CT-2000-30032
Finanziato nell'ambito di: FP5-INCO 2
Paese: Brazil

Generation of vectors for optimised expression of Sm14 antigens

We have obtained a strain expressing Sm14 from Schistosoma mansoni using a codon-optimized sm14 gene. This construct increased expression levels 4-fold. This strain induced a cellular Th1-type immune response specific for Sm14. We have also obtained expression of Sm14 in rBCG by a complemented LeuD- BCG auxotroph.

Reported by

Instituto Butantan
Av. Vital Brasil 1500
05503-900 Sao Paulo
Brazil
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