Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

FP5

RECOMBINANT BCG Informe resumido

Project ID: ICA4-CT-2000-30032
Financiado con arreglo a: FP5-INCO 2
País: Brazil

generation of rBCG strains expressing sm14 antigen

We have generated recombinant BCG strains that express the Schistosoma mansoni antigen, Sm14, in fusion with the beta-lactamase protein and signal sequence. Expression was obtained using a plasmid containing the upregulated beta-lactamase promoter, pBlaF. We have expressed Sm14 in BCG from the native gene. These rBCG-Sm14 strains induced a cellular Th1-type immune response, demonstrated by IFN-g production of cultured splenocytes upon stimulation with rSm14.

Contacto

Luciana LEITE, (Head of Unit)
Tel.: +55-11-37269150
Correo electrónico
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