Community Research and Development Information Service - CORDIS

FP5

RECOMBINANT BCG Report Summary

Project ID: ICA4-CT-2000-30032
Funded under: FP5-INCO 2
Country: United Kingdom

generation of rBCG strains lacking immunodominant antigens

Genes encoding the antigens mpb63 and mpb83 were eliminated from BCG Pasteur by allelic exchange to generate BCG-delta strains.

These BCG-delta strains may be useful as alternative BCG vaccine strains.

Vaccination with these strains will generate immunity against tuberculosis but complementary diagnostic tests that target the mpb63 and mpb83 antigens may be used to distinguish BCG vaccination from natural infection with M. bovis or M. tuberculosis.

Contact

Johnjoe MCFADDEN, (Professor of Molecular Genetics)
Tel.: +44-1483686494
Fax: +44-1483300374
E-mail
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