Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

FP5

RECOMBINANT BCG Sintesi della relazione

Project ID: ICA4-CT-2000-30032
Finanziato nell'ambito di: FP5-INCO 2
Paese: United Kingdom

generation of rBCG strains lacking immunodominant antigens

Genes encoding the antigens mpb63 and mpb83 were eliminated from BCG Pasteur by allelic exchange to generate BCG-delta strains.

These BCG-delta strains may be useful as alternative BCG vaccine strains.

Vaccination with these strains will generate immunity against tuberculosis but complementary diagnostic tests that target the mpb63 and mpb83 antigens may be used to distinguish BCG vaccination from natural infection with M. bovis or M. tuberculosis.

Contatto

Johnjoe MCFADDEN, (Professor of Molecular Genetics)
Tel.: +44-1483686494
Fax: +44-1483300374
E-mail