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effect of PTHrP on in vitro and in vivo vitellogenin production

During reproduction E2 is the main hormone responsible for the induction of vitellogenin production, a process that induces a large increase in extracellular calcium and phosphorus. Using a PTHrP antagonist (7-34 PTHrP), we have been able to block the E2-induced rise in calcium and phosphorus, thus demonstrating that PTHrP mediates at least in part the hypercalcemic effect of E2 in calcium balance. This result may be important to understand the factors that contribute for egg quality.

Reported by

Radboud University Nijmegen
Toernooiveld 1
6525 ED Nijmegen
Netherlands
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