Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Optimal stimulation parameters for suppressing or inducing bladder contraction

One of the main goals within the REBEC project was to improve the efficacy of neuromodulation therapy. One of the research topics dealing with this issue was to develop and evaluate optimised stimulation signals for neuromodulation and neurostimulation treatment using newly developed arbitrary stimulation generators.

The newly developed signals enable selective stimulation (neuromodulation) of unmyelinated nerve fibres within e.g. the sacral nerve bundles. These signals have proven to be more effective in the inhibition of bladder instabilities in the animal model than the standard rectangular signals used in conventional stimulation generators. They seem to affect mainly the sensory afferent nerve fibres and allow higher stimulation amplitudes without undesirable motor responses and therefore can allow a significant increase of the responder rate to neuromodulation therapy.

Furthermore these signals could also improve other neurostimulation and neuromodulation techniques as e.g. deep brain stimulation in parkinsons disease and should be evaluated in further scientific studies. However, these signals could not be implemented in conventional stimulators, as they require different electronics and tripolar stimulation electrodes. As long as no certified implantable system is available this technique cannot be tested in humans. But REBEC provides the basics and information for the use of this new neurostimulation technique in other clinical fields also.

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