Service Communautaire d'Information sur la Recherche et le Développement - CORDIS

New genetically manipulated mice where components of the MAPK/ERK pathway are constitutively or conditionally ablated for the analysis of the physiological functions of the MAPK/ERK pathway

In the course of the project, we have developed genetically manipulated mice where components of the MAPK/ERK pathway are constitutively or conditionally ablated. The main value of the result obtained is of scientific nature, and resides in the knowledge acquired on the function of the proteins of the MAPK cascade in the context of the whole organism. The descriptions of the result have been/will be published in a series of publication from the partner labs, and thus disseminated to the scientific community.

The result is being/will be used by the partners themselves, to carry out specific scientific projects, and by other scientists without the consortium who are interested in exploiting our models to ask a specific question in their system. We have already received a large number of such requests, and have complied with most of them. Biomedical/pharma companies value the expertise and the knowledge we are accumulating on these eminently druggable kinase module. In particular, the results has the potential, and has already, revealed alternative targets of the kinases in the pathway; and it has predictive value in the context of the possible side effects of therapeutic approaches aimed at interfering with a given component of the pathway. Both issues are eminently relevant when evaluating the suitability of a given protein as a therapeutic target.

Reported by

INSTITUTE OF MICROBIOLOGY AND GENETICS - VIENNA BIOCENTER
Dr. Bohrgasse 9
1030 WIEN
Austria
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