Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

FP5

MAPK SIGNALLING Informe resumido

Project ID: QLG2-CT-2001-02278
Financiado con arreglo a: FP5-LIFE QUALITY
País: Austria

New mouse models for human diseases, including neuronal degeneration, multistage carcinogenesis and tumour angiogenesis

In the course of the project, we have developed new mouse models for human diseases, including neuronal degeneration, multistage carcinogenesis and tumour angiogenesis. They arise from the genetically manipulated mice where components of the MAPK/ERK pathway are constitutively or conditionally ablated, described in result 26965.

The main value of the result obtained is of scientific nature, and resides in the knowledge acquired on the function of the proteins of the MAPK cascade in the context of cancer development and neuronal development. The descriptions of the result will soon be published in a series of publication from the partner labs, and thus disseminated to the scientific community. The result is being/will be used by the partners themselves, to carry out specific scientific projects, and by other scientists without the consortium who are interested in exploiting our models to ask a specific question in their system.

We have already received a large number of such requests, and have complied with most of them. Biomedical/pharma companies value the expertise and the knowledge we are accumulating on these eminently druggable kinase module. In particular, the results has the potential, and has already, revealed alternative targets of the kinases in the pathway; and it has predictive value in the context of both the efficacy and the possible side effects of therapeutic approaches aimed at interfering with a given component of the pathway. Both issues are eminently relevant when evaluating the suitability of a given protein as a therapeutic target.

Contacto

Manuela BACCARINI, (Associate Professor, Group leader)
Tel.: +43-1427754607
Fax: +43-142779546
Correo electrónico
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