Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS


TRI-EX Berichtzusammenfassung

Project ID: QLG2-CT-2001-01673
Gefördert unter: FP5-LIFE QUALITY
Land: Portugal

New mammalian cellular models of OPMD

We generated mouse muscle cell lines that express either normal or OPMD-associated PABPN1 transgenes.

Contrasting to previous reports in the literature, we demonstrated that equivalent numbers of nuclear inclusions are formed in our PABPN1 wild-type and +7ala transfected cell lines, suggesting that it is merely the presence of the transgene that is the key to the formation of these structures.

This result was made public through a publication in a scientific journal.


Carmo FONSECA, (Principal Scientist)
Tel.: +351-21-7999411
Fax: +351-21-7999412
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