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New mammalian cellular models of OPMD

We generated mouse muscle cell lines that express either normal or OPMD-associated PABPN1 transgenes.

Contrasting to previous reports in the literature, we demonstrated that equivalent numbers of nuclear inclusions are formed in our PABPN1 wild-type and +7ala transfected cell lines, suggesting that it is merely the presence of the transgene that is the key to the formation of these structures.

This result was made public through a publication in a scientific journal.

Reported by

FUNDAÇÃO DA UNIVERSIDADE DE LISBOA
Faculdade de Medicina, Av Prof. Egas Moniz, Edif. Egas Moniz
1649-028 LISBOA
Portugal
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