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NUTRIENT IRON TOXICI Résumé de rapport

Project ID: QLK1-CT-2002-00444
Financé au titre de: FP5-LIFE QUALITY
Pays: Netherlands

High dietary haem iron increases the risk for coronary heart disease in women

A role for iron in the risk of ischaemic heart disease has been supported by in vitro and in vivo studies. We investigated whether dietary haem iron intake is associated with coronary heart disease (CHD) risk in a large population-based cohort of middle-aged women. We used data of 16 136 women aged 49 70 years at recruitment between 1993 and 1997. Follow-up was complete until 1 January 2000 and 252 newly diagnosed CHD cases were documented. Cox proportional hazards analysis was used to estimate hazard ratios of CHD for quartiles of haem iron intake, adjusted for cardiovascular and nutritional risk factors.

We strati.ed by the presence of additional cardiovascular risk factors, menstrual periods, and antioxidant intake to investigate the possibility of effect modi.cation. High dietary haem iron intake was associated with a 65% increase in CHD risk [hazard ratio (HR) 1/4 1.65; 95% con.dence interval (CI): 1.07 2.53], after adjustment for cardiovascular and nutritional risk factors. This risk was not modi.ed by additional risk factors, menstruation, or antioxidant intake.

Conclusion: The results indicate that middle-aged women with a relatively high haem iron intake have an increased risk of CHD.

Informations connexes


Yvonne VAN DER SCHOUW, (Associate Professor of Clinical Epidemiology)
Tél.: +31-887559360
Fax: +31-887568099