Servicio de Información Comunitario sobre Investigación y Desarrollo - CORDIS

Clonality and persistance of CMV specific CD8 T cells

In the present study we have verified and extended our previous on the immune risk phenotype in the elderly. To this end, we have conducted a thorough longitudinal study of nonagenarian, and showed that the number of expanded CD8 T cell clones is higher in non-IRP than IRP nonagenarians or middle-aged controls. Nonetheless, MHC/peptide multimer staining indicated that the number of CMV specific T cells was greater in nonagenarians than in middle-aged controls, although the ratio of functionally-intact cells was significantly lower. The lowest ratio of functional CMV specific T cells was found in an IRP individual. Data from a thorough longitudinal analysis of the CMV specific T cells in nonagenarians, showed a very stable pattern both with respect to frequency, phenotype and clonal composition.

We hypothesize that the number of CD8 T cell clones expands as the individual ages, possibly as a compensatory mechanism to control latent infections, e.g. CMV, but eventually reach a point upon which clonal exhaustion leads to shrinkage of the CD8 clonal repertoire, associated with decreased survival. These data are in press in The Journal of Immunology, and thus will disseminate to the scientific community. Although there is no immidiate commercial implementation use, a future use of these data in terms of generating therapeutic interventions to protect the elderly from infection seems likely.

Moreover, the methedological combination of pheno- and clonotype analyses may set the stage for future monitoring of immune status using additional parameters. Together, our data may have an impact on the scientific community, and the health status and quality of life, particularly in the elderly.

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Contacto

Anders WIKBY, (Associate Professor)
Tel.: +46-38-135101
Correo electrónico
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