Community Research and Development Information Service - CORDIS

Generation of targeted microarrays for ED assays

Our experiments provided a system by which small ologonucleotides from specific genes could be bound to glass surfaces containing a three dimensional matrix. These gene sequences could be used to investigate the effect of endocrine disruption.
It is viewed that one of the effects of ED may ell be a change in gene expression, by measuring the effect in different tissues in response to a range of potential EDs than a diagnostic could be made.

Such slides, as well as the technology to produce similar arrays and to read arrays could have wide ranging uses. Instead of studying single genes multiple gene families can give an indication of exposure and by accumulating many samples, can also give an indication of mechanism.

For Genetix the work is important as it can validate the use of array and scanner technology and maintain the R and D in this highly competitive area as well as sustaining and providing new jobs.

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Julian BURKE, (Scientific Director)
Tel.: +44-1425-624600
Fax: +44-1425-624700
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