Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Mechanisms of HIV-induced cell death

The subject matter of the present invention relates to an in vitro method for the screening of anti-HIV compounds, or for predicting the progression of HIV related diseases, or for determining the efficiency of an anti-HIV-1 treatment based on the measuring of the expression level of Puma and, optionally, on the measuring of the phosphorylated P53 and/or the p38 MAP kinase protein level in circulating white blood cells of a sample from a HIV infected patient, particularly HIV-1. The invention further comprises a method for the diagnostic of HIV infection in a patient and kits for performing these methods.

Reported by

Centre Nationale de la Recherche Scientifique (CNRS) UMR8125
Institut Gustave Roussy, 39 rue Camille Desmoulins
94805 Villejuif
France