Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

New form of ARF tumor suppressor in mitochondria

This result centers on the identification of a novel smaller form of the ARF tumor suppressor protein. Unlike the regular ARF protein, which is almost exclusively a nuclear protein, this smaller form (smARF) localizes to mitochondria, where it causes loss of mitochondrial membrane potential and slow cell death.

This activity of smARF does not depend on the presence of functional p53 in the tumor cells, unlike the regular ARF protein, whose tumor suppressor activity is largely (albeit not exclusively) dependent on its ability to activate p53. The contribution of smARF to tumor cell death and its utility as a new target for activation by anti cancer agents need to be explored.

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