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Strategy for identification of epitope clusters useful as CTL vaccine components

Strategy for identification of epitope clusters useful as CTL-inducing vaccine components.

Most CTL epitopes in HIV antigens are concentrated in clusters. We found a strong correlation between the CTL epitope clusters and the degree of hydrophobicity of protein regions. Therefore, the hydrophilicity/hydrophobicity profile might be very useful for selecting protein regions for the production of potent, recombinant CTL-inducing HIV-vaccines.

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Max-Planck-Institut für Immunbiologie
Stübeweg 51
79108 Freiburg
Germany
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