Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

FP5

ASIARESIST Streszczenie raportu

Project ID: ICA4-CT-2001-10028
Źródło dofinansowania: FP5-INCO 2
Kraj: Vietnam

Antimicrobial multi-resistance in heterotrophic bacteria originating from Southeast Asian aquaculture origin

A total of 558 chloramphenicol (CHL) resistant bacterial isolates originating from aquaculture farms in Thailand, Malaysia and Vietnam were tested against 6 antimicrobials used in aquaculture, agriculture and human medicine.

Results of antibiotic susceptibility testing by the disk diffusion method showed that resistance to CHL alone was relatively rare (4%). The majority of isolates tested (59%) exhibited multi-resistance to three or four antibiotics in addition to CHL and this finding was common to all the countries and sample types including water, sediment and cultured organisms. A common component of the most dominant profiles (42%) was resistance to CHL, ampicillin, tetracycline with/or without resistance to trimethoprim/sulfamethoxazole.

In contrast, the CHL-resistant isolates (28%) were found to be relatively more susceptible to norfloxacin. There is evidence that Gram-negative bacteria displayed a significant difference on CHL resistance to that of Gram positive and the same pattern was found between families of Gram-negative. The minimum inhibitory concentrations (MICs) for CHL were also determined for the resistant isolates using a broth macrodilution method. Eighty three percent of the resistant isolates showed high CHL MIC ³ 512 ppm. There was a tendency for MIC to increase in the more multi-resistant isolates (resistant to CHL + 3 - 5 antibiotics).

This finding is also true to CHL resistant isolates belong to Gram-negative bacteria. Distribution of MICs values was significant difference between Gram-negative and Gram-positive isolates as well as between families of Gram-negative. However, there are no statistical differences of MICs values between Gram-positive families.

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