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Synthesis of GlcN-alfa-(1-4) Glc disaccharide

The title disaccharide was synthesized in 10 overall steps from commercial D-glucosamine and the properly protected allyl beta-D-glucopyranoside. This disaccharide is an intermediate for the synthesis of the non reducing end of the family of pentasaccharides putative substrates and/or inhibitors of the heparanase enzyme.

Reported by

THE UNIVERSITY OF MILANO
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