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Synthesis of the protected pentasaccharide GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, precursor of a small family of potential heparanase inhibitors

The protected pentasaccharide GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, precursor of a small family of potential heparanase inhibitors, was synthesized by coupling of the properly protected disaccharide GlcN-alfa-(1-4)-Glc with the protected trisaccharide GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe. This compound, by selective deprotection/sulfation, and final total deprotection, will lead to a small family of partially sulfated oligosaccharides of general structure GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, potential inhibitors of the heparanase enzime.

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Enrico DECLEVA, (CHANCELLOR)
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