Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

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  • Synthesis of the protected pentasaccharide GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, precursor of a small family of potential heparanase inhibitors
FP5

HEPARANASE Streszczenie raportu

Project ID: QLK3-CT-2002-02049
Źródło dofinansowania: FP5-LIFE QUALITY
Kraj: Italy

Synthesis of the protected pentasaccharide GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, precursor of a small family of potential heparanase inhibitors

The protected pentasaccharide GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, precursor of a small family of potential heparanase inhibitors, was synthesized by coupling of the properly protected disaccharide GlcN-alfa-(1-4)-Glc with the protected trisaccharide GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe. This compound, by selective deprotection/sulfation, and final total deprotection, will lead to a small family of partially sulfated oligosaccharides of general structure GlcN-alfa-(1-4) Glc-beta-(1-4) GlcN-alfa-(1-4) IdoA-alfa-(1-4)GlcN-1-alfa-OMe, potential inhibitors of the heparanase enzime.

Kontakt

Enrico DECLEVA, (CHANCELLOR)
Tel.: +39-025-0314060
Faks: +39-025-0314061
Adres e-mail
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