Community Research and Development Information Service - CORDIS

FP5

HEPARANASE Report Summary

Project ID: QLK3-CT-2002-02049
Funded under: FP5-LIFE QUALITY
Country: Italy

Synthesis of C-C glycomimetics of sulfated oligosaccharides

Sulfated C-glycosides oligosaccharide-like mimics were synthesized via formation of a direct C-C bond involving the anomeric or the 6 positions having different flexibility. The apply synthetic methodology can provide a panel of sulfate C-glycoside oligosaccharides mimics that are a new heparanase inhibitors class. It is expected that they could be resistant to enzymatic cleavage in vivo conditions and have good pharmacokinetics.

Contact

Torri GIANGIACOMO, (Head of science of carbohydrate dep)
Tel.: +39-027-0641624
Fax: +39-027-0641634
E-mail
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top