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HEPARANASE Résumé de rapport

Project ID: QLK3-CT-2002-02049
Financé au titre de: FP5-LIFE QUALITY
Pays: Italy

Synthesis of C-C glycomimetics of sulfated oligosaccharides

Sulfated C-glycosides oligosaccharide-like mimics were synthesized via formation of a direct C-C bond involving the anomeric or the 6 positions having different flexibility. The apply synthetic methodology can provide a panel of sulfate C-glycoside oligosaccharides mimics that are a new heparanase inhibitors class. It is expected that they could be resistant to enzymatic cleavage in vivo conditions and have good pharmacokinetics.


Torri GIANGIACOMO, (Head of science of carbohydrate dep)
Tél.: +39-027-0641624
Fax: +39-027-0641634