Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

FP5

HEPARANASE Sintesi della relazione

Project ID: QLK3-CT-2002-02049
Finanziato nell'ambito di: FP5-LIFE QUALITY
Paese: Italy

Synthesis of C-C glycomimetics of sulfated oligosaccharides

Sulfated C-glycosides oligosaccharide-like mimics were synthesized via formation of a direct C-C bond involving the anomeric or the 6 positions having different flexibility. The apply synthetic methodology can provide a panel of sulfate C-glycoside oligosaccharides mimics that are a new heparanase inhibitors class. It is expected that they could be resistant to enzymatic cleavage in vivo conditions and have good pharmacokinetics.

Contatto

Torri GIANGIACOMO, (Head of science of carbohydrate dep)
Tel.: +39-027-0641624
Fax: +39-027-0641634
E-mail