Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Synthesis of C-C glycomimetics of sulfated oligosaccharides

Sulfated C-glycosides oligosaccharide-like mimics were synthesized via formation of a direct C-C bond involving the anomeric or the 6 positions having different flexibility. The apply synthetic methodology can provide a panel of sulfate C-glycoside oligosaccharides mimics that are a new heparanase inhibitors class. It is expected that they could be resistant to enzymatic cleavage in vivo conditions and have good pharmacokinetics.

Reported by

G. Ronzoni Institute
via G. Colombo 81
2133 Milano
Italy
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