Servizio Comunitario di Informazione in materia di Ricerca e Sviluppo - CORDIS

Synthesis of C-C glycomimetics of sulfated oligosaccharides

Sulfated C-glycosides oligosaccharide-like mimics were synthesized via formation of a direct C-C bond involving the anomeric or the 6 positions having different flexibility. The apply synthetic methodology can provide a panel of sulfate C-glycoside oligosaccharides mimics that are a new heparanase inhibitors class. It is expected that they could be resistant to enzymatic cleavage in vivo conditions and have good pharmacokinetics.

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G. Ronzoni Institute
via G. Colombo 81
2133 Milano
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